Usually, to update i1Profiler software, it is not needed to un-install the previous software.
However, if there is a need to un-install the software for troubleshooting or other reasons, please follow these steps:
Disconnect all measurement instruments (if connected)
Disconnect your dongle (if connected)
Move the 'i1Profiler' program folder into the trash
Navigate to MacHD/Users/<username>/Library/Preferences and delete the i1Profiler Preferences file com.x-rite.i1Profiler.plist
Note: i1Profiler installs a folder structure, in which your custom Assets and Workflow Settings will be saved. If you want to delete it, navigate to MacHD/Library/Application Support/X-Rite/i1Profiler and move it to the trash (you might want to save a copy before deleting it).
Note: i1Profiler generates a couple of helpful Log Files. If you want to delete them, review this article.