The current version of MonacoPROFILER does not provide direct support in the measurement device options for the i1iO or the iSis.
However, you may generate and measure your targets using ColorPort Utility software. ColorPort allows you to save your measured data as a PROFILER session file (as well as other formats), and can even set MonacoPROFILER to automatically open as soon as your file is saved.
To download a copy of ColorPort, go here.
Any of the versions of ColorPort from 1.5.4 and upwards will offer connectivity for the i1iO and i1iSis to a MonacoPROFILER user.